Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces.

ABSTRACT: Objective.Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective translation requires increasing the efficacy and predictability of neural interface performance. Here we use computational models of rat visceral nerve to predict how neuroanatomical variability could affect both electrical stimulation and recording with an experimental planar neural interface.Approach.We developed a hybrid computational pipeline,VisceralNerveEnsembleRecording andStimulation (ViNERS), to couple finite-element modelling of extracellular electrical fields with biophysical simulations of individual axons. Anatomical properties of fascicles and axons in rat pelvic and vagus nerves were measured or obta

SUBMITTER: Eiber CD 

PROVIDER: S-EPMC8903799 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature