Is there a difference in the efficacy of COVID-19 vaccine in males and females? - A systematic review and meta-analysis.

ABSTRACT:

Introduction

Females generally have higher antibody responses to viral vaccines. Our objectives were to compare gender differences in the efficacy of COVID-19 vaccination.

Methods

Data sources: Studies from PubMed, Embase, Cochrane Central Register, Web of Science, ClinicalTrials.gov, and the World Health Organization's International Clinical Trials Registry Platform.

Results

We included four eligible trials; all were categorized as having a low risk of bias. COVID-19 vaccine was significantly effective in both males and females. Slightly more SARS-CoV-2 infections were recorded in females than in males, but the difference was not significant (RR 1.064 [0.888-1.274]; p = .502, I2 = 5.7%; p = .367, 643,127 participants).

Conclusion

Despite signific

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC8903917 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature