Environmental Dependence of Competitive Fitness in Rifampin-Resistant rpoB Mutants of Bacillus subtilis.

ABSTRACT: RNA polymerase (RNAP) is a highly conserved macromolecular machine that contributes to the flow of genetic information from genotype to phenotype. In Bacillus subtilis, mutations in the rpoB gene encoding the β-subunit of RNAP have been shown to alter a number of global phenotypes, including growth, utilization of unusual nutrient sources, sporulation, germination, and production of secondary metabolites. In addition, the spectrum of mutations in rpoB leading to rifampin resistance (Rif^r) can change dramatically depending upon the environment to which B. subtilis cells or spores are exposed. Rif^rrpoB mutations have historically been associated with slower growth and reduced fitness; however, these assessments of fitness were conducted on limited c

SUBMITTER: Leehan JD 

PROVIDER: S-EPMC8904044 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature