Plasmodium falciparum Cysteine Rich Secretory Protein uniquely localizes to one end of male gametes.

ABSTRACT: Fertilization is a central event during the life cycle of most eukaryotic organisms and involves gamete recognition and fusion, ultimately resulting in zygote formation. Gamete fertilization in the malaria-causing Plasmodium parasites occurs inside the mosquito midgut and represents a major bottleneck in the life cycle. Cysteine Rich Secretory Proteins (CRISPs) are key molecules involved in fertilization in vertebrates and the presence of a CRISP ortholog in human malaria infective Plasmodium falciparum suggested a possible role in fertilization. Strikingly, P. falciparum CRISP exhibited a unique terminal localization in the male microgamete. Parasites with a CRISP gene deletion (P. falciparum crisp^-) proliferated asexually similar to wildtype NF54 parasites and differentiated i

SUBMITTER: Kumar S 

PROVIDER: S-EPMC8904303 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature