An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.

ABSTRACT:

Background

Allergic asthma is a chronic airway inflammatory disease associated with airway mucus hyper-production. ILC2 cells, which express the Th2 transcription factor GATA3, have been associated with allergic asthma. The cytokine IL-3 is known to support eosinophil, basophil and mucosal mast cell differentiation and survival; however, its role on T regulatory cells as well as on lung ILC2 and in pediatric asthma needs further investigation.

Objectives

To investigate the role of IL-3 in preschool children and to explore its therapeutic role in experimental asthma.

Methods

In a cohort of preschool children with and without asthma, we analyzed the secretion of IL-3 in nasopharyngeal fluid (NPF) and IL-3 receptor (R) alpha chain mRNA expression in peripheral blood mono

SUBMITTER: Krammer S 

PROVIDER: S-EPMC8904351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature