A host non-coding RNA, nc886, plays a pro-viral role by promoting virus trafficking to the nucleus.

ABSTRACT: Elucidation of the interplay between viruses and host cells is crucial for taming viruses to benefit human health. Cancer therapy using adenovirus, called oncolytic virotherapy, is a promising treatment option but is not robust in all patients. In addition, inefficient replication of human adenovirus in mouse hampered the development of an in vivo model for preclinical evaluation of therapeutically engineered adenovirus. nc886 is a human non-coding RNA that suppresses Protein Kinase R (PKR), an antiviral protein. In this study, we have found that nc886 greatly promotes adenoviral gene expression and replication. Remarkably, the stimulatory effect of nc886 is not dependent on its function to inhibit PKR. Rather, nc886 facilitates the nuclear entry of adenovirus via modulating the kin

SUBMITTER: Saruuldalai E 

PROVIDER: S-EPMC8904404 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature