Regulation of Cell Delamination During Cortical Neurodevelopment and Implication for Brain Disorders.

ABSTRACT: Cortical development is dependent on key processes that can influence apical progenitor cell division and progeny. Pivotal among such critical cellular processes is the intricate mechanism of cell delamination. This indispensable cell detachment process mainly entails the loss of apical anchorage, and subsequent migration of the mitotic derivatives of the highly polarized apical cortical progenitors. Such apical progenitor derivatives are responsible for the majority of cortical neurogenesis. Many factors, including transcriptional and epigenetic/chromatin regulators, are known to tightly control cell attachment and delamination tendency in the cortical neurepithelium. Activity of these molecular regulators principally coordinate morphogenetic cues to engender remodeling or disassembly of

SUBMITTER: Sokpor G 

PROVIDER: S-EPMC8904418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature