Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer.

ABSTRACT: Lung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential anticancer agents for non-small cell lung cancer A-549, H226, and H460 cell lines. Most of the compounds efficiently inhibited the growth of all the tested cancer cell lines at micromolar concentrations. One of the most active compounds (PCH-1) was further evaluated for its effect on cell cycle distribution, apoptosis, migration, epithelial-mesenchymal trans

SUBMITTER: Maciejewska N 

PROVIDER: S-EPMC8904451 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature