Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits.

ABSTRACT: The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits  to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. 'Physical activity' and 'General Health' were the exposure categories containing the highest number of 'tentative signals' in analyses assessing the average association of lifestyle variables, while 'Tobacco use' was the top category for the 10-y

SUBMITTER: Poveda A 

PROVIDER: S-EPMC8904494 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature