Stability, dissolution, and cytotoxicity of NaYF₄-upconversion nanoparticles with different coatings.

ABSTRACT: Upconversion nanoparticles (UCNPs) have attracted considerable attention owing to their unique photophysical properties. Their utilization in biomedical applications depends on the understanding of their transformations under physiological conditions and their potential toxicity. In this study, NaYF₄:Yb,Er UCNPs, widely used for luminescence and photophysical studies, were modified with a set of four different coordinatively bound surface ligands, i.e., citrate, alendronate (AA), ethylendiamine tetra(methylene phosphonate) (EDTMP), and poly(maleic anhydride-alt-1-octadecene) (PMAO), as well as silica coatings with two different thicknesses. Subsequently, the aging-induced release of fluoride ions in water and cell culture media and their cytotoxic profile to human keratinocytes

SUBMITTER: Bastos V 

PROVIDER: S-EPMC8904531 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature