Ontology highlight
ABSTRACT:
SUBMITTER: Hu Z
PROVIDER: S-EPMC8904583 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Hu Zhengtao Z Yu Pengpeng P Zhang Yangyang Y Yang Yin Y Zhu Manyi M Qin Shuangying S Xu Ji-Tian JT Duan Dongxiao D Wu Yong Y Wang Deguo D Rowan Michael J MJ Hu Neng-Wei NW
Translational psychiatry 20220308 1
Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated stress response (ISR) via multiple pathologies including neuronal hyperactivation, microvascular hypoxia, and neuroinflammation. Increasing eIF2α phosphorylation, the core event of ISR, facilitates metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), and suppressing its phosphorylation has the opposite effect. Having found the facilitation of mGluR5-LTD by Aβ in live rats, we wondere ...[more]