Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population.

ABSTRACT: Recent studies have showed the diverse genetic architecture of the highly consanguineous populations inhabiting the Arabian Peninsula. Consanguinity coupled with heterogeneity is complex and makes it difficult to understand the bases of population-specific genetic diseases in the region. Therefore, comprehensive genetic characterization of the populations at the finest scale is warranted. Here, we revisit the genetic structure of the Kuwait population by analyzing genome-wide single nucleotide polymorphisms data from 583 Kuwaiti individuals sorted into three subgroups. We envisage a diverse demographic genetic history among the three subgroups based on drift and allelic sharing with modern and ancient individuals. Furthermore, our comprehensive haplotype-based analyses disclose a high gene

SUBMITTER: Eaaswarkhanth M 

PROVIDER: S-EPMC8904638 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature