Histone H2AX promotes metastatic progression by preserving glycolysis via hexokinase-2.

ABSTRACT: Genomic stability is essential for organismal development, cellular homeostasis, and survival. The DNA double-strand breaks are particularly deleterious, creating an environment prone to cellular transformation and oncogenic activation. The histone variant H2AX is an essential component of the nucleosome responsible for initiating the early steps of the DNA repair process. H2AX maintains genomic stability by initiating a signaling cascade that collectively functions to promote DNA double-strand breaks repair. Recent advances have linked genomic stability to energetic metabolism, and alterations in metabolism were found to interfere with genome maintenance. Utilizing genome-wide transcripts profiling to identify differentially-expressed genes involved in energetic metabolism, we compared co

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8904825 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature