Oral cancer induced TRPV1 sensitization is mediated by PAR₂ signaling in primary afferent neurons innervating the cancer microenvironment.

ABSTRACT: Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model using two-bottle choice drinking and conditioned place aversion assays. An anatomic basis of chemosensitivity is shown in increased expression of TRPV1 in anatomically relevant trigeminal ganglion (TG) neurons in both the xenograft and a carcinogen (4-nitroquinoline 1-oxide)-induced oral cancer mouse models. The percent of retrograde labeled TG neurons that respond to TRPV1 agonist, capsaicin, is increased along with the magnitude of response as measured by calcium influx, in neurons from the cancer models. To address the possible mechanism of TRPV1 sens

SUBMITTER: Scheff NN 

PROVIDER: S-EPMC8904826 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature