Ontology highlight
ABSTRACT:
SUBMITTER: Scheff NN
PROVIDER: S-EPMC8904826 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Scheff Nicole N NN Wall Ian M IM Nicholson Sam S Williams Hannah H Chen Elyssa E Tu Nguyen H NH Dolan John C JC Liu Cheng Z CZ Janal Malvin N MN Bunnett Nigel W NW Schmidt Brian L BL
Scientific reports 20220308 1
Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model using two-bottle choice drinking and conditioned place aversion assays. An anatomic basis of chemosensitivity is shown in increased expression of TRPV1 in anatomically relevant trigeminal ganglion (TG) neurons in both the xenograft and a carcinogen (4-nitroqui ...[more]