Stereotactic body radiotherapy for lung metastases in a patient with giant cell tumor of bone: a case report and literature review.

ABSTRACT: Giant cell tumor of bone (GCTB) is a rare borderline tumor which can develop lung metastasis. Guidelines for patients with multiple pulmonary metastases recommend systemic therapies, such as denosumab and interferons (IFNs). However, when both of these treatment approaches fail, no satisfactory options are available. Thus, additional treatments for GCTB after failure of standard treatment would be beneficial. Here we present a patient with GCTB and multiple pulmonary metastases who was treated with stereotactic body radiotherapy (SBRT) after failure of surgery, denosumab, and bisphosphonates (BPs). This is the first well-documented report of a patient with metastatic GCTB who received lung SBRT after the failure of systemic therapy and achieved a favorable response. Some of the patient's p

SUBMITTER: Feng L 

PROVIDER: S-EPMC8904985 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature