Assessing the impact of monocular deprivation on visual evoked potentials, behavior, and visual plasticity in juvenile mice.

ABSTRACT:

Background

The physiological mechanisms which underlie amblyopia are predicted using animal models which assess the impact of amblyogenic factors on visual function. This study used monocular-deprived mice as an amblyopic model to assess visual function by flash visual evoked potentials (fVEP), behavioral assessment, and visual plasticity.

Methods

A total of 294 C57BL/6J mice (both genders) were used in this study. The mice were divided into the normal control (NC) group and monocular deprivation (MD) group. After mice were anesthetized with pentobarbital, fVEP was recorded. Long-term potentiation (LTP) was recorded from primary visual cortex slices. Behavioral assessment of visual function was performed using a visual water trapezoidal-shaped pool with a release chute, a hi

SUBMITTER: Ding S 

PROVIDER: S-EPMC8904994 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature