Mechanical thrombectomy versus medical care alone in large ischemic core: An up-to-date meta-analysis.

ABSTRACT:

Objective

We compared outcomes and adverse events of thrombectomy versus medical management in acute ischemic stroke (AIS) patients with baseline large infarct core.

Methods

We searched Ovid MEDLINE(R) ALL, Cochrane Library Clinical Controlled Trials and EMBASE from inception to January 2021 for studies comparing thrombectomy and medical management alone in AIS patients who had ASPECTS <=7 or ischemic core volume >=50 ml. Imaging modalities to valuate ASPECTS and core volume were without restriction. The functional outcome was measured by mRS (modified Rankin Scale) score 0-2 at 90 days or discharge. The safety end point included the rates of mortality and sICH (symptomatic intracranial hemorrhage) or PH2 (parenchymal hematoma type 2).

Results

Fourteen studies with a

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC8905077 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature