Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.

ABSTRACT: Intestinal barrier immaturity, or "leaky gut", is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. Exacerbated intestinal immune responses, gut microbiota dysbiosis, and heightened barrier injury are considered primary triggers of aberrant intestinal maturation in early life. Inordinate host immunity contributes to this process, but the precise elements remain largely uncharacterized, leaving a significant knowledge gap in the biological underpinnings of gut maturation. In this study, we investigated the fecal cytokine profile and gut microbiota in a cohort of 40 early preterm infants <33-weeks-gestation to identify immune markers of intestinal barrier maturation. Three distinct microbiota types were demonstrated to be differentially associated with i

SUBMITTER: Lemme-Dumit JM 

PROVIDER: S-EPMC8905226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature