Differences in potential key genes and pathways between primary and radiation-associated angiosarcoma of the breast.

ABSTRACT:

Background

Angiosarcoma of the breast is a high-grade malignant soft tissue tumor, it can be divided into primary and radiation-associated angiosarcoma(secondary). However, the differences between primary and secondary angiosarcomas in terms of pathogenesis, clinical behavior, early diagnosis biomarkers, genetic abnormalities, and therapeutic targets remain to be fully elucidated. At the same time, due to its rarity, most of current information relating to angiosarcoma is provided by case reports. Therefore, exploring the mechanisms of primary and secondary breast angiosarcoma have important value for the discovery of new biomarkers and research into potential therapeutic targets.

Methods

The differentially expressed genes (DEGs) between 36 cases of primary angiosarcoma and

SUBMITTER: Wei Y 

PROVIDER: S-EPMC8905315 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature