Automated Quantification of Brain Lesion Volume From Post-trauma MR Diffusion-Weighted Images.

ABSTRACT:

Objectives

Determining the volume of brain lesions after trauma is challenging. Manual delineation is observer-dependent and time-consuming and cannot therefore be used in routine practice. The study aimed to evaluate the feasibility of an automated atlas-based quantification procedure (AQP) based on the detection of abnormal mean diffusivity (MD) values computed from diffusion-weighted MR images.

Methods

The performance of AQP was measured against manual delineation consensus by independent raters in two series of experiments based on: (i) realistic trauma phantoms (n = 5) where low and high MD values were assigned to healthy brain images according to the intensity, form and location of lesion observed in real TBI cases; (ii) severe TBI patients (n = 12 patien

SUBMITTER: Mistral T 

PROVIDER: S-EPMC8905597 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature