Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level.

ABSTRACT:

Background

Mature blood cells arise from hematopoietic stem cells in the bone marrow by a process of differentiation along one of several different lineage trajectories. This is often represented as a series of discrete steps of increasing progenitor cell commitment to a given lineage, but as for differentiation in general, whether the process is instructive or stochastic remains controversial. Here, we examine this question by analyzing single-cell transcriptomic data from human bone marrow cells, assessing cell-to-cell variability along the trajectories of hematopoietic differentiation into four different types of mature blood cells. The instructive model predicts that cells will be following the same sequence of instructions and that there will be minimal variability of gene exp

SUBMITTER: Dussiau C 

PROVIDER: S-EPMC8905725 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature