Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways.

ABSTRACT:

Background

Colon cancer (CC) ranks the second highest mortality rate among malignant tumors worldwide, and the current mainstream treatment regimens are not very effective. The unique efficacy of Chinese herb medicine (CHM) for cancer has recently attracted increasing attention. Cinnamomi Ramulus (CR), as a classic CHM, has been widely used in the treatment of a variety of diseases for hundreds of years in China, but its specific pharmacological mechanism against CC needs to be fully evaluated.

Methods

TCMSP and China National Knowledge Infrastructure database were utilized to predict the candidate ingredients of CR, and TCMSP and SwissTargetPrediction database were also employed to predict the drug targets of the candidate ingredients from CR. We subsequently evaluated the

SUBMITTER: Pan B 

PROVIDER: S-EPMC8905814 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature