Does the incorporation of strontium into calcium phosphate improve bone repair? A meta-analysis.

ABSTRACT:

Background

The application of calcium phosphate (CaP)-based bone substitutes plays an important role in periodontal regeneration, implant dentistry and alveolar bone reconstruction. The incorporation of strontium (Sr) into CaP-based bone substitutes appears to improve their biological properties, but the reported in vivo bone repair performance is inconsistent among studies. Herein, we conducted a systematic review and meta-analysis to investigate the in vivo performance of Sr-doped materials.

Methods

We searched PubMed, EMBASE (via OVIDSP), and reference lists to identify relevant animal studies. The search, study selection, and data extraction were performed independently by two investigators. Meta-analyses and sub-group analyses were conducted using Revman version 5.4.1.

SUBMITTER: Yan MD 

PROVIDER: S-EPMC8905839 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature