Mechanistic insights into the C₅₅-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.

ABSTRACT: The continued rise of antibiotic resistance is a global concern that threatens to undermine many aspects of modern medical practice. Key to addressing this threat is the discovery and development of new antibiotics that operate by unexploited modes of action. The so-called calcium-dependent lipopeptide antibiotics (CDAs) are an important emerging class of natural products that provides a source of new antibiotic agents rich in structural and mechanistic diversity. Notable in this regard is the subset of CDAs comprising the laspartomycins and amphomycins/friulimicins that specifically target the bacterial cell wall precursor undecaprenyl phosphate (C₅₅-P). In this study we describe the design and synthesis of new C₅₅-P-targeting CDAs with structural features drawn from

SUBMITTER: Wood TM 

PROVIDER: S-EPMC8905900 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature