Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization.

ABSTRACT: Some risk factors for severe coronavirus disease 2019 (COVID-19) have been identified, including age, race, and obesity. However, 20%-50% of severe cases occur in the absence of these factors. Cytomegalovirus (CMV) is a herpesvirus that infects about 50% of all individuals worldwide and is among the most significant nongenetic determinants of immune system. We hypothesized that latent CMV infection might influence the severity of COVID-19. Our analyses demonstrate that CMV seropositivity is associated with more than twice the risk of hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune profiling of blood and CMV DNA quantitative polymerase chain reaction in a subset of patients for whom respiratory tract samples were available revealed alter

SUBMITTER: Alanio C 

PROVIDER: S-EPMC8905965 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature