Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.

ABSTRACT:

Background

It is known that inflammatory responses play an important role in the pathophysiology of COVID-19.

Aims

In this study, we aimed to examine the role of kynurenine (KYN) metabolism on the severity of COVID-19 disease AQ5.

Materials & methods

Seventy COVID-19 patients of varying severity and 30 controls were included in the study. In addition to the classical laboratory parameters, KYN, tryptophan (TRP), kynurenic acid (KYNA), 3 hydroxykynurenine (3OHKYN), quinolinic acid (QA), and picolinic acid (PA) were measured with mass spectrometry.

Results

TRP, KYN, KYN:TRP ratio, KYNA, 3OHKYN, PA, and QA results were found to be significantly different in COVID-19 patients (p < 0.001 for all). The KYN:TRP ratio and PA of severe COVID-19 patients was statisticall

SUBMITTER: Cihan M 

PROVIDER: S-EPMC8906035 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature