Computation and visualization of cell-cell signaling topologies in single-cell systems data using Connectome.

ABSTRACT: Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell-cell and ligand-receptor connectivity that influence the function of tissues and organs. However, the quantification and visualization of these patterns in a way that informs tissue biology are major computational and epistemological challenges. Here, we present Connectome, a software package for R which facilitates rapid calculation and interactive exploration of cell-cell signaling network topologies contained in single-cell RNA-sequencing data. Connectome can be used with any reference set of known ligand-receptor mechanisms. It has built-in functionality to facilitate differential and comparative connectomics, in which signaling networks are compared between tissue systems. Connectome f

SUBMITTER: Raredon MSB 

PROVIDER: S-EPMC8906120 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature