Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling.

ABSTRACT: The use of botanical dietary supplements for the alleviation of conditions such as hot flashes, premenstrual syndrome, and fertility is prolific worldwide. Estrogen and progesterone receptors (ER and PR) and their corresponding steroid hormones are critical for the relief of hot flashes and the treatment of patients who develop endometriosis, and these pathways can influence the development of endometrial, ovarian, and breast cancers. However, few studies have investigated or identified the natural product components in herbal supplements that act on the PR. In the current study, a new secoiridoid, demethoxy-cornuside (1), along with six known secoiridoids (2-7) were isolated from the twigs of dogwood (Cornus officinalis) by bioassay-guided isolation with a prog

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8906238 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature