Can soluble urokinase plasminogen receptor predict outcomes after cardiac surgery?

ABSTRACT:

Objectives

Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that has been implicated in several cardiac pathologies and has been shown to be elevated in critically ill populations. We measured plasma suPAR in a cohort of cardiac surgical patients to evaluate its ability to predict prolonged intensive care unit (ICU) and hospital length of stay and development of complications following surgery. We compared suPAR against EuroSCORE II and C-reactive protein (CRP).

Methods

Ninety patients undergoing cardiac surgery were recruited with samples taken preoperatively and on postoperative days 1, 2 and 3. suPAR was measured using enzyme-linked immunosorbent assay. Area under the receiver operator curve (AUROC) was used to test predictive capability of suPAR. C

SUBMITTER: Schultz-Swarthfigure CT 

PROVIDER: S-EPMC8906672 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature