Longitudinal associations between adolescents' individualised risk for depression and inflammation in a UK cohort study.

ABSTRACT: Inflammation is associated with poor physical and mental health including major depressive disorder (MDD). Moreover, there is evidence that childhood adversity - a risk factor for MDD - becomes biologically embedded via elevated inflammation. However, the risk of developing MDD arises from multiple sources and yet there has been little investigation of the links between individuals' constellation of MDD risk and subsequent inflammation. We therefore examined associations between individual risk for MDD calculated in early adolescence and levels of inflammation six years later. We use data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative UK birth cohort of 2,232 children followed to age 18 with 93% retention. Participants' individual risk for develop

SUBMITTER: Latham RM 

PROVIDER: S-EPMC8906711 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature