Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies.

ABSTRACT:

Background

Development of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment interruption, but there is uncertainty regarding whether modern antiretroviral therapy (ART) regimens and timing of ART initiation may affect this outcome.

Methods

AIDS Clinical Trials Group (ACTG) A5345 enrolled individuals who initiated ART during chronic or early HIV infection and on suppressive ART for ≥2 years. Participants underwent carefully monitored antiretroviral interruption. ART was restarted upon 2 successive viral loads ≥1000 copies/mL. We compared participants of A5345 with participants of 6 historic ACTG treatment interruption studies.

Results

Thirty-three chronic-treated and 12 early-treated participants

SUBMITTER: Li JZ 

PROVIDER: S-EPMC8906742 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature