Hypothermia for cardiogenic encephalopathy in neonates with dextro-transposition of the great arteries.

ABSTRACT:

Objectives

Neonates with dextro-transposition of the great arteries (d-TGA) may experience rapid haemodynamic deterioration and profound hypoxaemia after birth. We report on d-TGA patients with severe acidosis, encephalopathy and their treatment with systemic hypothermia.

Methods

This study is a single-centre retrospective cohort analysis of newborns with d-TGA.

Results

Ninety-five patients (gestational age ≥35 weeks) with d-TGA and intended arterial switch operation were included. Ten infants (10.5%) with umbilical arterial blood pH > 7.10 experienced profound acidosis (pH < 7.00) within the first 2 h of life. Six of these patients displayed signs of encephalopathy and received therapeutic hypothermia. Apgar scores at 5 min independently predicted the development of

SUBMITTER: Boos V 

PROVIDER: S-EPMC8906748 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature