Risk of Pelvic Fracture With Radiation Therapy in Older Patients.

ABSTRACT:

Purpose

Older patients undergoing radiation therapy (RT) for pelvic malignancies are at increased risk for pelvic fracture, which is associated with significant morbidity and mortality. RT techniques such as brachytherapy or intensity modulated RT (IMRT) allow for more conformal dose distributions, but it is not known whether the risk for pelvic fracture varies by RT modality.

Methods and materials

This observational cohort study involved 28,354 patients ≥65 years old, treated with RT for pelvic malignancies. We evaluated the relative risk of pelvic fracture by type of RT when accounting for baseline factors. To test for nonspecific effects, we also evaluated risk of nonpelvic fractures in the same population.

Results

The 5-year incidence of pelvic fractures was 12.7%

SUBMITTER: Vitzthum LK 

PROVIDER: S-EPMC8906845 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature