Structural connectivity of the sensorimotor network within the non-lesioned hemisphere of children with perinatal stroke.

ABSTRACT: Perinatal stroke occurs early in life and often leads to a permanent, disabling weakness to one side of the body. To test the hypothesis that non-lesioned hemisphere sensorimotor network structural connectivity in children with perinatal stroke is different from controls, we used diffusion imaging and graph theory to explore structural topology between these populations. Children underwent diffusion and anatomical 3T MRI. Whole-brain tractography was constrained using a brain atlas creating an adjacency matrix containing connectivity values. Graph theory metrics including betweenness centrality, clustering coefficient, and both neighbourhood and hierarchical complexity of sensorimotor nodes were compared to controls. Relationships between these connectivity metrics and validated sensorimot

SUBMITTER: Craig BT 

PROVIDER: S-EPMC8907195 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature