Computational identification of new potential transcriptional partners of ERRα in breast cancer cells: specific partners for specific targets.

ABSTRACT: Estrogen related receptors are orphan members of the nuclear receptor superfamily acting as transcription factors (TFs). In contrast to classical nuclear receptors, the activities of the ERRs are not controlled by a natural ligand. Regulation of their activities thus relies on availability of transcriptional co-regulators. In this paper, we focus on ERRα, whose involvement in cancer progression has been broadly demonstrated. We propose a new approach to identify potential co-activators, starting from previously identified ERRα-activated genes in a breast cancer (BC) cell line. Considering mRNA gene expression from two sets of human BC cells as major endpoint, we used sparse partial least squares modeling to uncover new transcriptional regulators associated with ERRα. Among them, DDX21, MYB

SUBMITTER: Cerutti C 

PROVIDER: S-EPMC8907200 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature