Role of senescent cells in the motile behavior of active, non-senescent cells in confluent populations.

ABSTRACT: Characteristics of cell migration in a confluent population depend on the nature of cell-to-cell interactions as well as cell-intrinsic properties such as the directional persistence in crawling. In addition, biological tissues (or cell cultures) almost always carry anisotropies and they too can significantly affect cell motility. In the light of this viewpoint, the emergence of cellular senescences in a confluent population of active cells raises an interesting question. Cellular senescence is a process through which a cell enters a permanent growth-arrest state and generally exhibits a dramatic body expansion. Therefore, randomly emerging senescent cells transform an initially homogeneous cell population to a "binary mixture" of two distinct cell types. Here, using in vitro cultures of M

SUBMITTER: Gabuardi TL 

PROVIDER: S-EPMC8907270 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature