First-in-human immunoPET imaging of HIV-1 infection using ⁸⁹Zr-labeled VRC01 broadly neutralizing antibody.

ABSTRACT: A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. HIV largely resides in anatomical regions that are inaccessible to routine sampling, however, and non-invasive methods to understand the longitudinal tissue-wide burden of HIV persistence are urgently needed. Positron emission tomography (PET) imaging is a promising strategy to identify and characterize the tissue-wide burden of HIV. Here, we assess the efficacy of using immunoPET imaging to characterize HIV reservoirs and identify anatomical foci of persistent viral transcriptional activity using a radiolabeled HIV Env-specific broadly neutralizing antibody, ⁸⁹Zr-VRC01, in HIV-

SUBMITTER: Beckford-Vera DR 

PROVIDER: S-EPMC8907355 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature