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2-Alkylation of 3-Alkyindoles With Unactivated Alkenes.


ABSTRACT: An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields.

SUBMITTER: Pan X 

PROVIDER: S-EPMC8907451 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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2-Alkylation of 3-Alkyindoles With Unactivated Alkenes.

Pan Xuling X   Liu Qian Q   Nong Yingling Y  

Frontiers in chemistry 20220224


An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields. ...[more]

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