Myocardial infarct border demarcation by dual-wavelength photoacoustic spectral analysis.

ABSTRACT: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Modern therapeutic strategies targeting the infarct border area have been shown to benefit overall cardiac function after MI. However, there is no non-invasive diagnostic technique to precisely demarcate the MI boundary till to now. In this study, the feasibility of demarcating the MI border using dual-wavelength photoacoustic spectral analysis (DWPASA) was investigated. To quantify specific molecular characteristics before and after MI, "the ratio of the areas of the power spectral densities (R _APSD)" was computed from the DWPASA results. Compared to the normal tissue, MI tissue was shown to contain more collagen, resulting in higher R _APSD values (p < 0.001). Cross

SUBMITTER: Ma K 

PROVIDER: S-EPMC8907670 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature