LMO1 Plays an Oncogenic Role in Human Glioma Associated With NF-kB Pathway.

ABSTRACT:

Background

LIM domain only protein1(LMO1), a nuclear transcription coregulator, is implicated in the pathogenesis of T-cell acute lymphoblastic leukemia and neuroblastoma. However, the clinical significance and potential mechanism of LMO1 in human gliomas remain to be determined.

Methods

In this study, expression level data and clinical information were obtained via three databases. The Cox proportional hazards regression model was used to predict outcomes for glioma patients. In vitro and in vivo assays were used to explore the function of LMO1 in human glioma. Gene set enrichment analysis (GSEA), RNA-seq and western blot were used to explore the potential molecular mechanisms. A prognostic model was built for predicting the overall survival(OS) of huma

SUBMITTER: Gao L 

PROVIDER: S-EPMC8907846 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature