Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences.

ABSTRACT:

Background

The study was aimed at encapsulating the evidence of in vitro and in vivo antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2, the pathogen responsible for COVID-19, and finding out the efficacy and safety of molnupiravir in clinical trials.

Main body

Information on publications was explored on several databases, gray literature was reviewed, and the outcomes were discussed narratively. Molnupiravir's antiviral efficacy and associated mechanism of action have been verified in vitro against both non-COVID and multiple coronaviruses. Molnupiravir has been tried in preclinical investigations in numerous animal models against non-coronaviruses. Clinical studies in several countries are now being conducted to evaluate its antiv

SUBMITTER: Singla S 

PROVIDER: S-EPMC8907909 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature