Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Background and objectives

Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior.

Methods

A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the ALDH2 rs671 polymorphism as an instru

SUBMITTER: Yang JH 

PROVIDER: S-EPMC8907994 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature