ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.

ABSTRACT: Zinc finger protein 36 like 1 (ZFP36L1) enhances the turnover of mRNAs containing AU-rich elements (AREs) in their 3'-untranslated regions (3'UTR). The physiological and pathological functions of ZFP36L1 in liver, however, remain largely unknown. Liver-specific ZFP36L1-deficient (Zfp36l1^flox/flox/Cre⁺; L1^LKO) mice were generated to investigate the role of ZFP36L1 in liver physiology and pathology. Under normal conditions, the L1^LKO mice and their littermate controls (Zfp36l1^flox/flox/Cre^-; L1^FLX) appeared normal. When fed a Lieber-DeCarli liquid diet containing alcohol, L1^LKO mice were significantly protected from developing alcohol-induced hepatic steatosis, injury, and inflammation compared with L1

SUBMITTER: Bathula CS 

PROVIDER: S-EPMC8908057 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature