LncRNA SNHG12 promotes the malignant progression of melanoma by targeting miR-199b.

ABSTRACT:

Background

Melanoma is a type of tumor caused by the malignant transformation of melanocytes, and has a high degree of malignancy. Small nucleolar RNA host gene 12 (SNHG12) plays an important role in a variety of cancers, but its role in melanoma and its mechanisms are still unclear. In this study, we measured the expression of SNHG12 and explored the molecular mechanisms involved in melanoma.

Methods

We detected the expression level of SNHG12 in melanoma cell lines, and explored the effect of SNHG12 on the proliferation, migration, and invasion of melanoma cells in vitro. Mechanistic studies explored the regulation of downstream genes by SNHG12.

Results

Overexpression of SNHG12 was found in melanoma cell lines,

SUBMITTER: Xie Y 

PROVIDER: S-EPMC8908113 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature