Establishment and validation of a novel immune-related prognostic signature in malignant pleural mesothelioma.

ABSTRACT:

Background

Immune-related genes (IRGs) play an important role in the tumor immune microenvironment and affect tumor prognosis. This study aimed to establish a prognostic signature for malignant pleural mesothelioma (MPM) patients.

Methods

We obtained the relevant data of MPM patients in The Cancer Genome Atlas (TCGA), and univariate and multivariate Cox regression were used to construct the prediction signature and verify it with the external validation dataset GSE2549. A nomogram was then constructed, and its predictive ability was evaluated and analyzed the level of immune cell infiltration in different groups in the signature.

Results

An IRG-related prognostic signature composed of INHBA, CAT, SORT1, TNFSF13B, and BIRC5 was constructed, with patients

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8908124 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature