The prognostic significance of a novel ferroptosis-related gene model in breast cancer.

ABSTRACT:

Background

Breast cancer (BRCA) is the most common malignancy with high heterogeneity in women, and the prognostic prediction for BRCA has remained poor. Ferroptosis, a recently identified iron-dependent form of programmed cell death, plays a significant role in BRCA treatment. Some BRCA cell lines are proven to be sensitive to ferroptosis, and some ferroptosis-related genes have been identified as divers or suppressors in the progress of BRCA. This study aimed to explore the prognostic value of ferroptosis-related genes in BRCA.

Methods

A ferroptosis-related gene list, messenger RNA (mRNA) gene expression of BRCA patients, and corresponding clinicopathological data were collected from public databases. The patients of the Cancer Genome Atlas (TCGA) were identified as the tr

SUBMITTER: Lu YJ 

PROVIDER: S-EPMC8908135 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature