Mechanism of protective role of miR-874-3p in intervertebral disc degeneration.

ABSTRACT:

Background

The intervertebral disc can increase the amplitude of spinal motion, withstand pressure, buffer vibration, and protect the brain and spinal cord. It is also the main reason why height changes, but the regulatory mechanism is still unclear, and this study mainly explored the role of miR-874-3p in intervertebral disc degeneration (IDD).

Methods

The mechanism and perform correlation analysis of miR-874-3p and the pathological degree and prognosis of patients with IDD. miR-874-3p is involved in the progression of several diseases, such as cell differentiation, proliferation, apoptosis and extracellular matrix degradation, overexpressing cell line GV369-miR-874-3p-NP was obtained by infected nucleus pulposus (NP) cells, and the empty vector GV369-NP group was set with

SUBMITTER: Yang X 

PROVIDER: S-EPMC8908150 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature