Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma.

ABSTRACT:

Background

Transfer RNA-derived fragments (tRFs) and transfer RNA halves (tiRNAs) have been shown to play crucial roles in gene regulation. This study aims to reveal the expression profiles of tRFs and tiRNAs and their possible biological roles in lung adenocarcinoma (LUAD).

Methods

Five paired clinical lung adenocarcinoma tissues (LAT) and adjacent normal lung tissues (ANLT) were selected to analyze the expression of tRFs and tiRNAs. Six significantly expressed tRFs and tiRNAs were selected and validated by Quantitative Real-time PCR (qPCR). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed.

Results

The sequencing results showed that 109 tRFs and tiRNAs were differentially expressed between LAT and ANLT,

SUBMITTER: Huang LT 

PROVIDER: S-EPMC8908152 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature