The Effects of Modified Intermittent Fasting in Psoriasis (MANGO): Protocol for a Two-Arm Pilot Randomized Controlled Open Cross-over Study.

ABSTRACT:

Background

Psoriasis is a complex disease associated with multiple comorbidities, including metabolic syndrome and leaky gut syndrome. Dietary lifestyle interventions have been reported to affect the disease in terms of lesional severity. It remains unclear how diets affect these comorbidities and the general health in psoriasis patients. Modified intermittent fasting (MIF) on 2 nonconsecutive days has shown beneficial effects on metabolic parameters. A significant advantage of MIF over the currently investigated dietary changes is its feasibility.

Objective

Here, we aim to study the effects of MIF on skin, gut, and metabolic health in psoriasis patients.

Methods

A 2-arm pilot randomized controlled open cross-over study will be performed in 24 patients with psoriasis.

SUBMITTER: Grine L 

PROVIDER: S-EPMC8908196 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature