SARS-CoV-2 shedding sources in wastewater and implications for wastewater-based epidemiology.

ABSTRACT: Wastewater-based epidemiology (WBE) approach for COVID-19 surveillance is largely based on the assumption of SARS-CoV-2 RNA shedding into sewers by infected individuals. Recent studies found that SARS-CoV-2 RNA concentration in wastewater (C_RNA) could not be accounted by the fecal shedding alone. This study aimed to determine potential major shedding sources based on literature data of C_RNA, along with the COVID-19 prevalence in the catchment area through a systematic literature review. Theoretical C_RNA under a certain prevalence was estimated using Monte Carlo simulations, with eight scenarios accommodating feces alone, and both feces and sputum as shedding sources. With feces alone, none of the WBE data was in the confidence interval of theoretical C

SUBMITTER: Li X 

PROVIDER: S-EPMC8908579 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature